Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection

Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection

One of the major challenges in the development of targeted nanoparticles (NPs) for cancer therapy is to discover targeting ligands that allow for differential binding and uptake by the target cancer cells. Using prostate cancer (PCa) as a model disease, we developed a cell-uptake selection strategy...

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Bibliographic Details
Main Authors: Xiao, Zeyu (Contributor), Levy-Nissenbaum, Etgar (Contributor), Alexis, Frank (Contributor), Luptak, Andrej (Author), Teply, Benjamin A. (Contributor), Chan, Juliana Maria (Contributor), Shi, Jinjun (Author), Digga, Elise (Author), Cheng, Judy (Contributor), Langer, Robert (Contributor), Farokhzad, Omid C. (Contributor)
Other Authors: MIT-Harvard Center for Cancer Nanotechnology Excellence (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Shi, JinJun (Contributor)
Format: Article
Language:English
Published: American Chemical Society, 2013-06-14T15:39:34Z.
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