The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

Phosphoinositide 3-kinase (PI3K) plays a critical role in tumorigenesis, and the PI3K p85 regulatory subunit exerts both positive and negative effects on signaling. Expression of Pik3r1, the gene encoding p85, is decreased in human prostate, lung, ovarian, bladder, and liver cancers, consistent with...

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Main Authors: Taniguchi, Cullen M. (Author), Winnay, Jonathon (Author), Kondo, Tatsuya (Author), Bronson, Roderick T. (Author), Guimaraes, Alexander R. (Author), Aleman, Jose O. (Contributor), Luo, Ji (Author), Stephanopoulos, Gregory (Contributor), Weissleder, Ralph (Author), Cantley, Lewis C. (Author), Kahn, C. Ronald (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2013-06-20T19:34:24Z.
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