Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA

Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA

Multilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer self-assembly and then delivered to the skin by microneedle application to a...

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Bibliographic Details
Main Authors: DeMuth, Peter Charles (Contributor), Su, Xingfang (Contributor), Samuel, Raymond E. (Contributor), Hammond, Paula T (Author), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hammond, Paula T. (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: Wiley-Blackwell Publishers, 2013-06-26T16:33:34Z.
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