Modeling the Insulin-Like Growth Factor System in Articular Cartilage

Modeling the Insulin-Like Growth Factor System in Articular Cartilage

IGF signaling is involved in cell proliferation, differentiation and apoptosis in a wide range of tissues, both normal and diseased, and so IGF-IR has been the focus of intense interest as a promising drug target. In this computational study on cartilage, we focus on two questions: (i) what are the...

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Main Authors: Zhang, Lihai (Author), Smith, David W. (Author), Gardiner, Bruce S. (Author), Grodzinsky, Alan J. (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Biomedical Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-09-13T17:28:48Z.
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