Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

Whole-genome sequencing using massively parallel sequencing technologies enables accurate detection of somatic rearrangements in cancer. Pinpointing large numbers of rearrangement breakpoints to base-pair resolution allows analysis of rearrangement microhomology and genomic location for every sample...

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Bibliographic Details
Main Authors: Drier, Yotam (Author), Lawrence, Michael S. (Author), Carter, Scott L. (Author), Stewart, Chip (Author), Gabriel, Stacey B. (Author), Meyerson, Matthew L. (Author), Beroukhim, Rameen (Author), Getz, Gad (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2013-09-18T14:19:06Z.
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