Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained via SCNT

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained via SCNT

Mice that are transgenic for rearranged antigen-specific T cell receptors (TCRs) are essential tools to study T cell development and function. Such TCRs are usually isolated from the relevant T cells after long-term culture, often after repeated antigen stimulation, which unavoidably skews the T cel...

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Main Authors: Suh, Heikyung (Contributor), Jaenisch, Rudolf (Contributor), Ploegh, Hidde (Contributor), Kirak, Oktay (Author), Frickel, Eva-Maria (Author), Grotenbreg, Gijsbert M. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2013-09-27T13:18:32Z.
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