Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

Despite optimal radiation therapy (RT), chemotherapy and/or surgery, a majority of patients with locally advanced non-small cell lung cancer (NSCLC) fail treatment. To identify novel gene targets for improved tumor control, we performed whole genome RNAi screens to identify knockdowns that most repr...

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Bibliographic Details
Main Authors: Cron, Kyle R. (Author), Zhu, Kaya (Author), Kushwaha, Deepa S. (Author), Hsieh, Grace (Author), Merzon, Dmitry (Author), Rameseder, Jonathan (Contributor), Chen, Clark C. (Author), D'Andrea, Alan D. (Author), Kozono, David (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-09-27T16:19:53Z.
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