Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice

Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice

A role for microbes has been suspected in prostate cancer but difficult to confirm in human patients. We show here that a gastrointestinal (GI) tract bacterial infection is sufficient to enhance prostate intraepithelial neoplasia (PIN) and microinvasive carcinoma in a mouse model. We found that anim...

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Bibliographic Details
Main Authors: Poutahidis, Theofilos (Contributor), Cappelle, Kelsey (Contributor), Levkovich, Tatiana (Contributor), Lee, Chung-Wei (Author), Doulberis, Michael (Author), Ge, Zhongming (Contributor), Fox, James G. (Contributor), Horwitz, Bruce H. (Author), Erdman, Susan E. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-09-30T13:55:15Z.
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