A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary - albeit often ineffective - treatment method, has remained largely unchanged over the past 50 years, highlighting th...

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Main Authors: Schroeder, Frederick A. (Author), Lewis, Michael C. (Contributor), Fass, Daniel M. (Author), Wagner, Florence F. (Author), Zhang, Yan-Ling (Author), Hennig, Krista M. (Author), Gale, Jennifer (Author), Zhao, Wen-Ning (Author), Reis, Surya (Author), Barker, Douglas D. (Author), Berry-Scott, Erin (Author), Kim, Sung Won (Author), Clore, Elizabeth L. (Author), Hooker, Jacob M. (Author), Holson, Edward B. (Author), Haggarty, Stephen J. (Contributor), Petryshen, Tracey (Contributor)
Other Authors: McGovern Institute for Brain Research at MIT (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-09-30T14:47:58Z.
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