Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

The transcription factor ΔFosB and the brain-enriched calcium/calmodulin-dependent protein kinase II (CaMKIIα) are induced in the nucleus accumbens (NAc) by chronic exposure to cocaine or other psychostimulant drugs of abuse, in which the two proteins mediate sensitized drug responses. Although ΔFos...

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Main Authors: Neve, Rachael L. (Contributor), Robison, Alfred J. (Author), Vialou, Vincent (Author), Mazei-Robison, Michelle S. (Author), Feng, Jian (Author), Kourrich, Said (Author), Collins, Miles (Author), Wee, Sunmee (Author), Koob, George (Author), Turecki, Gustavo (Author), Thomas, Mark (Author), Nestler, Eric J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor)
Format: Article
Language:English
Published: Society for Neuroscience, 2013-10-07T12:10:06Z.
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