Barnacle: detecting and characterizing tandem duplications and fusions in transcriptome assemblies

Barnacle: detecting and characterizing tandem duplications and fusions in transcriptome assemblies

Background: Chimeric transcripts, including partial and internal tandem duplications (PTDs, ITDs) and gene fusions, are important in the detection, prognosis, and treatment of human cancers. Results: We describe Barnacle, a production-grade analysis tool that detects such chimeras in de novo assembl...

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Main Authors: Swanson, Lucas (Author), Robertson, Gordon (Author), Mungall, Karen L. (Author), Butterfield, Yaron S. (Author), Chiu, Readman (Author), Corbett, Richard D. (Author), Docking, T. R. (Author), Hogge, Donna (Author), Jackman, Shaun D. (Author), Moore, Richard A. (Author), Mungall, Andrew J. (Author), Nip, Ka Ming (Author), Parker, Jeremy D. K. (Author), Qian, Jenny Q. (Author), Raymond, Anthony (Author), Sung, Sandy (Author), Tam, Angela (Author), Thiessen, Nina (Author), Varhol, Richard (Author), Wang, Sherry (Author), Yorukoglu, Deniz (Contributor), Zhao, YongJun (Author), Hoodless, Pamela A. (Author), Sahinalp, S. C. (Author), Karsan, Aly (Author), Birol, Inanc (Author), Qian, Jenny (Author), Sahinalp, S. (Author)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd., 2013-10-09T15:52:35Z.
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