A Bulky Biaryl Phosphine Ligand Allows for Palladium-Catalyzed Amidation of Five-Membered Heterocycles as Electrophiles
The incredible bulk: The first palladium-catalyzed amidation of five-membered heterocyclic bromides with multiple heteroatoms was achieved using the Pd/1 catalyst system. N-Arylated imidazoles, pyrazoles, thiazoles, pyrroles, and thiophenes were synthesized in moderate to excellent yield. Experiment...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley Blackwell,
2013-11-01T16:18:48Z.
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| Subjects: | |
| Online Access: | Get fulltext |