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|a Su, Mingjuan
|e author
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|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
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|a Su, Mingjuan
|e contributor
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|a Buchwald, Stephen Leffler
|e contributor
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|a Buchwald, Stephen Leffler
|e author
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|a A Bulky Biaryl Phosphine Ligand Allows for Palladium-Catalyzed Amidation of Five-Membered Heterocycles as Electrophiles
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|b Wiley Blackwell,
|c 2013-11-01T16:18:48Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/81944
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|a The incredible bulk: The first palladium-catalyzed amidation of five-membered heterocyclic bromides with multiple heteroatoms was achieved using the Pd/1 catalyst system. N-Arylated imidazoles, pyrazoles, thiazoles, pyrroles, and thiophenes were synthesized in moderate to excellent yield. Experimental results and DFT calculations point to the need for an electron-rich and sterically demanding biaryl phosphine ligand to promote these difficult reactions.
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|a National Institutes of Health (U.S.) (Grant GM58160)
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|a National Science Foundation (U.S.) (Grant CHE9808061)
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|a National Science Foundation (U.S.) (Grant DBI 9729592)
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|a National Science Foundation (U.S.) (CHE-0946721)
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|a en_US
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|a Article
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|t Angewandte Chemie International Edition
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