Physical Basis of Metal-Binding Specificity in Escherichia coli NikR

In Escherichia coli and other bacteria, nickel uptake is regulated by the transcription factor NikR. Nickel binding at high-affinity sites in E. coli NikR (EcNikR) facilitates EcNikR binding to the nik operon, where it then suppresses transcription of genes encoding the nickel uptake transporter, Ni...

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Bibliographic Details
Main Authors: Phillips, Christine M. (Contributor), Nerenberg, Paul S. (Contributor), Drennan, Catherine L (Author), Stultz, Collin M (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor), Drennan, Catherine L. (Contributor), Stultz, Collin M. (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2013-11-08T14:29:00Z.
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