Insight into the Mechanism of Inactivation of Ribonucleotide Reductase by Gemcitabine 5'-Diphosphate in the Presence or Absence of Reductant

Insight into the Mechanism of Inactivation of Ribonucleotide Reductase by Gemcitabine 5'-Diphosphate in the Presence or Absence of Reductant

Gemcitabine 5'-diphosphate (F[subscript 2]CDP) is a potent inhibitor of ribonucleotide reductases (RNRs), enzymes that convert nucleotides (NDPs) to deoxynucleotides and are essential for DNA replication and repair. The Escherichia coli RNR, an α2β2 complex, when incubated with 1 equiv of F[sub...

Full description

Bibliographic Details
Main Authors: Artin, Erin (Contributor), Wang, Jun (Contributor), Lohman, Gregory J. S. (Contributor), Yokoyama, Kenichi (Contributor), Yu, Guixue (Contributor), Bar, Galit (Contributor), Stubbe, JoAnne (Contributor), Griffin, Robert Guy (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2013-11-08T20:27:34Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items