Transimination of Quinone Imines: A Mechanism for Embedding Exogenous Redox Activity into the Nucleosome

Transimination of Quinone Imines: A Mechanism for Embedding Exogenous Redox Activity into the Nucleosome

Aminophenols can redox cycle through the corresponding quinone imines to generate ROS. The electrophilic quinone imine intermediate can react with protein thiols as a mechanism of immobilization in vivo. Here, we describe the previously unkown transimination of a quinone imine by lysine as an altern...

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Bibliographic Details
Main Authors: Ye, Wenjie (Contributor), Seneviratne, Uthpala I. (Contributor), Chao, Ming-Wei (Contributor), Wogan, Gerald N. (Contributor), Skipper, Paul L. (Contributor), Kodihalli, Ravindra (Contributor), Tannenbaum, Steven Robert (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2013-11-13T18:00:06Z.
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