Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan implicated as the primary matrix molecule responsible for vessel compression because...

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Bibliographic Details
Main Authors: Chauhan, Vikash P. (Author), Liu, Hao (Author), Lacorre, Delphine A. (Author), Jain, Saloni R. (Contributor), Kozin, Sergey V. (Author), Stylianopoulos, Triantafyllos (Author), Mousa, Ahmed S. (Author), Han, Xiaoxing (Author), Adstamongkonkul, Pichet (Author), Huang, Peigen (Author), Bawendi, Moungi G. (Contributor), Boucher, Yves (Author), Jain, Rakesh K. (Author), Martin, John Daniel (Contributor), Popovic, Zoran (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-11-25T17:20:30Z.
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