Identification of Aneuploidy-Selective Antiproliferation Compounds

Identification of Aneuploidy-Selective Antiproliferation Compounds

Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer therapies. We have identified the energy stress-inducing agent AICAR, the protein folding inhibitor 17-AAG, and the autophagy in...

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Bibliographic Details
Main Authors: Tang, Yun-Chi (Contributor), Williams, Bret R. (Contributor), Siegel, Jake J. (Contributor), Amon, Angelika B (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Amon, Angelika B. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2013-12-10T21:56:24Z.
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