Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

Genome-wide chromatin annotations have permitted the mapping of putative regulatory elements across multiple human cell types. However, their experimental dissection by directed regulatory motif disruption has remained unfeasible at the genome scale. Here, we use a massively parallel reporter assay...

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Bibliographic Details
Main Authors: Kheradpour, Pouya (Contributor), Kellis, Manolis (Contributor), Ernst, Jason (Author), Melnikov, Alexandre (Author), Rogov, Peter (Author), Wang, Li (Author), Zhang, Xiaolan (Author), Alston, Jessica (Author), Mikkelsen, Tarjei Sigurd (Author)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2013-12-13T14:45:12Z.
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