Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility

Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility

Cell motility requires lamellipodial protrusion, a process driven by actin polymerization. Ena/VASP proteins accumulate in protruding lamellipodia and promote the rapid actin-driven motility of the pathogen Listeria. In contrast, Ena/VASP negatively regulate cell translocation. To resolve this parad...

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Main Authors: Bear, James E. (Contributor), Svitkina, Tatyana M. (Author), Krause, Matthias (Contributor), Schafer, Dorothy A. (Author), Loureiro, Joseph J. (Contributor), Strasser, Geraldine A. (Contributor), Maly, Ivan V. (Author), Chaga, Oleg Y. (Author), Cooper, John A. (Author), Borisy, Gary G. (Author), Gertler, Frank (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-01-06T14:52:30Z.
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