Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine...

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Bibliographic Details
Main Authors: Zukerberg, Lawrence R (Author), Patrick, Gentry N (Author), Nikolic, Margareta (Author), Humbert, Sandrine (Author), Wu, Chin-Lee (Author), Vidal, Marc (Author), Van Etten, Richard A (Author), Tsai, Li-Huei (Author), Lanier, Lorene M. (Contributor), Gertler, Frank (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-01-06T16:19:19Z.
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