Statistical Experimental Design Guided Optimization of a One-Pot Biphasic Multienzyme Total Synthesis of Amorpha-4,11-diene

In vitro synthesis of chemicals and pharmaceuticals using enzymes is of considerable interest as these biocatalysts facilitate a wide variety of reactions under mild conditions with excellent regio-, chemo- and stereoselectivities. A significant challenge in a multi-enzymatic reaction is the need to...

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Bibliographic Details
Main Authors: Chen, Xixian (Contributor), Zhang, Congqiang (Contributor), Zou, Ruiyang (Author), Zhou, Kang (Contributor), Stephanopoulos, Gregory (Contributor), Too, Heng Phon (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Singapore-MIT Alliance in Research and Technology (SMART) (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-01-06T19:38:15Z.
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