Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. The effect of high levels of c-Myc on global gene regulation is poorly understood but is widely thought to involve newly activated or repressed...

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Bibliographic Details
Main Authors: Lin, Charles Y. (Contributor), Loven, Jakob (Contributor), Rahl, Peter B (Author), Paranal, Ronald M (Author), Burge, Christopher B. (Contributor), Bradner, James E. (Author), Lee, Tong Ihn (Contributor), Young, Richard A (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Rahl, Peter B. (Contributor), Young, Richard A. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2014-01-08T20:58:12Z.
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