Analysis and design of RNA sequencing experiments for identifying isoform regulation

Analysis and design of RNA sequencing experiments for identifying isoform regulation

Through alternative splicing, most human genes express multiple isoforms that often differ in function. To infer isoform regulation from high-throughput sequencing of cDNA fragments (RNA-seq), we developed the mixture-of-isoforms (MISO) model, a statistical model that estimates expression of alterna...

Full description

Bibliographic Details
Main Authors: Katz, Yarden (Contributor), Airoldi, Edoardo M. (Author), Wang, Eric T (Author), Burge, Christopher B (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Wang, Eric Tzy-shi (Contributor), Burge, Christopher B. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-01-08T22:00:15Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items