Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell metabolism, AcCoA is primarily generated from glucose-derived pyruvate through the citrate shuttle and ATP citrate lyase in the cytosol. Howeve...

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Main Authors: Metallo, Christian M. (Contributor), Gameiro, Paulo A. (Contributor), Bell, Eric L. (Contributor), Yang, Juanjuan (Author), Hiller, Karsten (Contributor), Jewell, Christopher M. (Contributor), Vander Heiden, Matthew G. (Contributor), Iliopoulos, Othon (Author), Stephanopoulos, Gregory (Contributor), Kelleher, Joanne Keene (Contributor), Mattaini, Katherine Ruth (Contributor), Guarente, Leonard Pershing (Contributor), Johnson, Zachary (Contributor), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-01-24T16:40:09Z.
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