SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a function in MSCs by creating MSC specific SIRT1 knock‐out (MSCKO) mice. Aged MSCKO...

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Bibliographic Details
Main Authors: Simic, Petra (Contributor), Zainabadi, Kayvan (Contributor), Sykes, David B. (Author), Saez, Borja (Author), Lotinun, Sutada (Author), Baron, Roland (Author), Scadden, David (Author), Schipani, Ernestina (Author), Bell, Eric L. (Contributor), Guarente, Leonard Pershing (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2014-01-24T17:40:34Z.
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