Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

Glioblastoma multiforme (GBM) is characterized by overexpression of epidermal growth factor receptor (EGFR) and loss of the tumor suppressors Ink4a/Arf. Efforts at modeling GBM using wild-type EGFR in mice have proven unsuccessful. Here, we present a unique mouse model of wild-type EGFR-driven gliom...

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Bibliographic Details
Main Authors: Whittaker, Charles A. (Contributor), Charest, Alain (Contributor), Acquaviva, Jaime (Author), Jun, Hyun Jung (Author), Lessard, Julie (Author), Ruiz, Rolando (Author), Zhu, Haihao (Author), Donovan, Melissa (Author), Woolfenden, Steve (Author), Boskovitz, Abraham (Author), Raval, Ami (Author), Bronson, Roderick T. (Author), Pfannl, Rolf (Author), Housman, David E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Housman, David E. (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2014-01-24T20:44:57Z.
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