Design of a Bioactive Small Molecule That Targets the Myotonic Dystrophy Type 1 RNA via an RNA Motif-Ligand Database and Chemical Similarity Searching

Design of a Bioactive Small Molecule That Targets the Myotonic Dystrophy Type 1 RNA via an RNA Motif-Ligand Database and Chemical Similarity Searching

Myotonic dystrophy type 1 (DM1) is a triplet repeating disorder caused by expanded CTG repeats in the 3'-untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The transcribed repeats fold into an RNA hairpin with multiple copies of a 5'CUG/3'GUC motif that binds...

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Bibliographic Details
Main Authors: Parkesh, Raman (Author), Childs-Disney, Jessica L. (Author), Nakamori, Masayuki (Author), Kumar, Amit (Author), Wang, Thomas (Contributor), Hoskins, Jason (Author), Thornton, Charles A. (Author), Disney, Matthew D. (Author), Housman, David E (Author), Wang, Eric T (Author), Tran, Tuan, M. Eng (Tuan Minh) (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Wang, Eric (Contributor), Housman, David E. (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2014-01-27T13:44:29Z.
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