Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

Activation of the eukaryotic replicative DNA helicase, the Mcm2-7 complex, requires phosphorylation by Cdc7/Dbf4 (Dbf4-dependent kinase or DDK), which, in turn, depends on prior phosphorylation of Mcm2-7 by an unknown kinase (or kinases). We identified DDK phosphorylation sites on Mcm4 and Mcm6 and...

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Main Authors: Randell, John C.W (Contributor), Chan, Clara Sophia (Contributor), Francis, Laura I. (Contributor), Heller, Ryan C. (Contributor), Bell, Stephen P. (Contributor), Galani, Kyriakitsa (Contributor), Fan, Andy 1976- (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Fan, Andy (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-01-27T17:33:16Z.
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