Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols

Efforts to improve the production of a compound of interest in Saccharomyces cerevisiae have mainly involved engineering or overexpression of cytoplasmic enzymes. We show that targeting metabolic pathways to mitochondria can increase production compared with overexpression of the enzymes involved in...

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Bibliographic Details
Main Authors: Stephanopoulos, Gregory (Contributor), Avalos, Jose L. (Contributor), Fink, Gerald R. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-01-27T19:03:29Z.
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