Predictive Bcl-2 Family Binding Models Rooted in Experiment or Structure
Proteins of the Bcl-2 family either enhance or suppress programmed cell death and are centrally involved in cancer development and resistance to chemotherapy. BH3 (Bcl-2 homology 3)-only Bcl-2 proteins promote cell death by docking an α-helix into a hydrophobic groove on the surface of one or more o...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier,
2014-01-31T17:00:23Z.
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| Subjects: | |
| Online Access: | Get fulltext |