Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically miss low-allelic-fraction mutations that occur in only a subset of the sequenced cells owing to either tumor heterogeneity or contamination by normal cells. Here we present...

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Bibliographic Details
Main Authors: Cibulskis, Kristian (Author), Sivachenko, Andrey (Author), Jaffe, David B. (Author), Sougnez, Carrie (Author), Gabriel, Stacey B. (Author), Meyerson, Matthew L. (Author), Getz, Gad (Author), Lawrence, Michael S. (Author), Carter, Scott L. (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-02-07T16:00:47Z.
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