Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins

Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins

The muscleblind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle and eye development and in myotonic dystrophy (DM), in which expanded CUG or CCUG repeats functionally deplete Mbnl proteins. We identified transcriptome-wide functional and biophysical targets of Mbnl protein...

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Main Authors: Cody, Neal A. L. (Author), Jog, Sonali (Author), Biancolella, Michela (Author), Wang, Thomas T. (Author), Treacy, Daniel J. (Contributor), Luo, Shujun (Author), Schroth, Gary P. (Author), Reddy, Sita (Author), Lécuyer, Eric (Author), Wang, Thomas (Contributor), Housman, David E (Author), Burge, Christopher B (Author), Wang, Eric T (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Wang, Eric Tzy-shi (Contributor), Housman, David E. (Contributor), Burge, Christopher B. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2014-02-07T18:14:57Z.
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