Pten-Null Tumors Cohabiting the Same Lung Display Differential AKT Activation and Sensitivity to Dietary Restriction

Pten-Null Tumors Cohabiting the Same Lung Display Differential AKT Activation and Sensitivity to Dietary Restriction

PTEN loss is considered a biomarker for activated phosphoinositide 3-kinase (PI3K)/AKT, a pathway frequently mutated in cancer, and was recently shown to confer resistance to dietary restriction. Here, we show that Pten loss is not sufficient to drive AKT activation and resistance to dietary restric...

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Bibliographic Details
Main Authors: Curry, Natasha L. (Author), Mino-Kenudson, Mari (Author), Oliver, Trudy (Contributor), Yilmaz, Omer (Contributor), Yilmaz, Vedat O. (Author), Moon, Jade Y. (Author), Jacks, Tyler E. (Contributor), Sabatini, David M. (Contributor), Kalaany, Nada Y. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2014-02-26T18:36:09Z.
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