Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases

Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases

The Src and Syk families of kinases are two distinct sets of kinases that play critical roles in initiating membrane-proximal B cell receptor (BCR) signaling. However, unlike in other lymphocytes, such as T cells, the "division of labor" between Src family kinases (SFKs) and Syk in B cells...

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Main Authors: Mukherjee, Sayak (Author), Zhu, Jing (Author), Zikherman, Julie (Author), Parameswaran, Ramya (Author), Kadlecek, Theresa A. (Author), Wang, Qi (Author), Au-Yeung, Byron (Author), Ploegh, Hidde (Contributor), Kuriyan, John (Author), Das, Jayajit (Author), Weiss, Arthur (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science, 2014-02-26T19:10:09Z.
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