Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Macropinocytosis is a highly conserved endocytic process by which extracellular fluid and its contents are internalized into cells through large, heterogeneous vesicles known as macropinosomes. Oncogenic Ras proteins have been shown to stimulate macropinocytosis but the functional contribution of th...

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Main Authors: Commisso, Cosimo (Author), Davidson, Shawn Michael (Contributor), Soydaner-Azeloglu, Rengin G. (Author), Parker, Seth J. (Author), Kamphorst, Jurre J. (Author), Hackett, Sean (Author), Grabocka, Elda (Author), Nofal, Michel (Author), Drebin, Jeffrey A. (Author), Thompson, Craig B. (Author), Rabinowitz, Joshua D. (Author), Metallo, Christian M. (Author), Vander Heiden, Matthew G. (Contributor), Bar-Sagi, Dafna (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-02-26T21:42:23Z.
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