DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the p38/MK2 pathway for survival after DNA damage, despite a functional ATR-Chk1 pa...

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Bibliographic Details
Main Authors: Reinhardt, H. Christian (Contributor), Hasskamp, Pia (Contributor), Schmedding, Ingolf (Contributor), Morandell, Sandra (Author), van Vugt, Marcel A.T.M (Author), Wang, XiaoZhe (Author), Linding, Rune (Author), Ong, Shao-En (Author), Weaver, David (Author), Carr, Steven A. (Author), Yaffe, Michael B (Author)
Other Authors: Massachusetts Institute of Technology. Cell Decision Process Center (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Yaffe, Michael B. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2014-02-27T16:40:53Z.
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