DHODH modulates transcriptional elongation in the neural crest and melanoma

DHODH modulates transcriptional elongation in the neural crest and melanoma

Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma1. We...

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Main Authors: White, Richard Mark (Author), Cech, Jennifer N. (Author), Ratanasirintrawoot, Sutheera (Author), Lin, Charles Y. (Contributor), Rahl, Peter B. (Contributor), Burke, Christopher J. (Author), Langdon, Erin (Author), Tomlinson, Matthew L. (Author), Mosher, Jack (Author), Kaufman, Charles (Author), Chen, Frank (Author), Long, Hannah K. (Author), Kramer, Martin (Author), Datta, Sumon (Author), Neuberg, Donna S. (Author), Granter, Scott (Author), Young, Richard A. (Contributor), Morrison, Sean (Author), Wheeler, Grant N. (Author), Zon, Leonard I. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-02-27T20:37:52Z.
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