PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and Aβ

PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and Aβ

Defects in p21-activated kinase (PAK) are suspected to play a role in cognitive symptoms of Alzheimer's disease (AD). Dysfunction in PAK leads to cofilin activation, drebrin displacement from its actin-binding site, actin depolymerization/severing, and, ultimately, defects in spine dynamics and...

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Main Authors: Tonegawa, Susumu (Contributor), Arsenault, Dany (Author), Dal-Pan, Alexandre (Author), Tremblay, Cyntia (Author), Bennett, David A. (Author), Guitton, Matthieu J. (Author), De Koninck, Yves (Author), Calon, Frederic (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Society for Neuroscience, 2014-02-28T14:11:40Z.
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