The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin structure are implicated in the initiation and propagation of the DNA damage response. Here we further investigate t...

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Main Authors: Floyd, Scott R. (Contributor), Pacold, Michael E. (Contributor), Huang, Qiuying (Contributor), Clarke, Scott M. (Contributor), Rameseder, Jonathan (Contributor), Lee, Michael J. (Contributor), Blake, Emily J. (Contributor), Fydrych, Anna (Contributor), Ho, Richard (Contributor), Del Rosario, Amanda M. (Contributor), Root, David E. (Author), Carpenter, Anne E. (Author), Hahn, William C. (Author), Sabatini, David M. (Contributor), Chen, Clark C. (Author), White, Forest M. (Contributor), Bradner, James E. (Author), Yaffe, Michael B. (Contributor), Lam, Fred Chiu-Lai (Contributor), Cannell, Ian Gordon (Contributor), Bryson, Bryan D. (Contributor), Greenberger, Benjamin Aaron (Contributor), Chen, Grace (Contributor), Maffa, Amanda D. (Contributor)
Other Authors: Whitaker College of Health Sciences and Technology (Contributor), Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-02-28T18:38:20Z.
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