Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
Cold Spring Harbor Laboratory Press,
2014-03-06T20:21:39Z.
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Subjects: | |
Online Access: | Get fulltext |