Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...

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Main Authors: Shi, Junwei (Author), Whyte, Warren A. (Contributor), Zepeda-Mendoza, Cinthya J. (Author), Milazzo, Joseph P. (Author), Shen, Chen (Author), Roe, Jae-Seok (Author), Minder, Jessica L. (Author), Mercan, Fatih (Author), Wang, Eric (Author), Eckersley-Maslin, Melanie A. (Author), Campbell, Amy E. (Author), Kawaoka, Shinpei (Author), Shareef, Sarah (Author), Zhu, Zhu (Author), Kendall, Jude (Author), Muhar, Matthias (Author), Haslinger, Christian (Author), Yu, Ming (Author), Roeder, Robert G. (Author), Wigler, Michael H. (Author), Blobel, Gerd A. (Author), Zuber, Johannes (Author), Spector, David L. (Author), Young, Richard A. (Contributor), Vakoc, Christopher R. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2014-03-06T20:21:39Z.
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