Promoter directionality is controlled by U1 snRNP and polyadenylation signals

Promoter directionality is controlled by U1 snRNP and polyadenylation signals

Transcription of the mammalian genome is pervasive, but productive transcription outside of protein-coding genes is limited by unknown mechanisms1. In particular, although RNA polymerase II (RNAPII) initiates divergently from most active gene promoters, productive elongation occurs primarily in the...

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Bibliographic Details
Main Authors: Almada, Albert Ernesto (Contributor), Wu, Xuebing (Contributor), Kriz, Andrea J. (Contributor), Sharp, Phillip A. (Contributor), Burge, Christopher B (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Burge, Christopher B. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-03-07T16:04:38Z.
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