ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State

ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State

Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397 kDa transcriptio...

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Main Authors: Chudnovsky, Yakov (Contributor), Kim, Dohoon (Contributor), Zheng, Siyuan (Author), Whyte, Warren A (Author), Bansal, Mukesh (Author), Bray, Mark-Anthony (Author), Gopal, Shuba (Author), Theisen, Matthew A (Author), Bilodeau, Steve (Author), Thiru, Prathapan (Contributor), Muffat, Julien (Contributor), Yilmaz, Omer (Contributor), Mitalipova, Maya (Contributor), Woolard, Kevin (Author), Lee, Jeongwu (Author), Nishimura, Riko (Author), Sakata, Nobuo (Author), Fine, Howard A. (Author), Carpenter, Anne E. (Author), Silver, Serena J. (Author), Verhaak, Roel G.W (Author), Califano, Andrea (Author), Young, Richard A. (Contributor), Ligon, Keith L. (Author), Mellinghoff, Ingo K. (Author), Root, David E. (Author), Hahn, William C. (Author), Chheda, Milan G. (Author), Sabatini, David (Author), Whyte, Warren Anthony (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor), Whyte, Warren A. (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2014-03-07T18:31:40Z.
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