Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum
Some nascent proteins that fold within the endoplasmic reticulum (ER) never reach their native state. Misfolded proteins are removed from the folding machinery, dislocated from the ER into the cytosol, and degraded in a series of pathways collectively referred to as ER-associated degradation (ERAD)....
| Main Authors: | , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS),
2014-03-10T17:58:46Z.
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| Subjects: | |
| Online Access: | Get fulltext |