Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself

Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself

Purpose: Previously, polymer-attached zanamivir had been found to inhibit influenza A viruses in vitro far better than did small-molecule zanamivir (1) itself. The aim of this study was to identify in vitro-using the plaque reduction assay-a highly potent 1-polymer conjugate, and subsequently test i...

Full description

Bibliographic Details
Main Authors: Belser, Jessica A. (Author), Tumpey, Terrence M. (Author), Chen, Jianzhu (Contributor), Klibanov, Alexander M. (Contributor), Weight, Alisha Kessel (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Weight, Alisha K. (Contributor)
Format: Article
Language:English
Published: Springer-Verlag, 2014-03-10T18:20:53Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items