Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number

Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a d...

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Bibliographic Details
Main Authors: Eng, Jennifer Christina (Contributor), Sankaran, Vijay G. (Author), Ludwig, Leif S. (Author), Sicinska, Ewa (Author), Xu, Jian (Author), Bauer, Daniel E. (Author), Patterson, Heide Christine (Author), Metcalf, Ryan A. (Author), Natkunam, Yasodha (Author), Orkin, Stuart H. (Author), Sicinski, Piotr (Author), Lander, Eric Steven (Author), Lodish, Harvey F (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Lander, Eric S. (Contributor), Lodish, Harvey F. (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2014-03-10T19:05:59Z.
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