mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

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The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein kinase promotes growth and is the target of rapamycin, a clinically useful drug that also prolongs life span in model organisms. A persistent mystery is why the phosphorylation of many bona fide mTORC1 substrates is resistant to r...

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Bibliographic Details
Main Authors: Cervantes, Christopher L. (Contributor), Lim, Daniel Cham-Chin (Contributor), Kang, Seong A. (Author), Pacold, Michael E. (Author), Lou, Hua Jane (Author), Ottina, Kathleen (Author), Gray, Nathanael S. (Author), Turk, Benjamin E. (Author), Yaffe, Michael B (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Yaffe, Michael B. (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2014-03-14T16:47:11Z.
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