Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends the life spans of yeast, flies, and mice. Calorie restriction, which increases life span and insulin sensitivity, is proposed to function by inhibition of mTORC1, yet paradoxically, chronic administration of rapam...

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Bibliographic Details
Main Authors: Lamming, Dudley W. (Contributor), Ye, Lan (Author), Katajisto, Pekka (Contributor), Goncalves, Marcus D. (Author), Saitoh, Maki (Contributor), Stevens, Deanna M. (Contributor), Davis, James G. (Author), Salmon, Adam B. (Author), Richardson, Arlan (Author), Ahima, Rexford S. (Author), Guertin, David A. (Contributor), Baur, Joseph A. (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science, 2014-03-19T19:54:11Z.
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