A Central Role for mTOR in Lipid Homeostasis

by Lamming, Dudley W, Sabatini, David M, Lamming, Dudley W., Sabatini, David
Published 2016

A Radical Role for TOR in Longevity

by Lamming, Dudley W, Sabatini, David M, Sabatini, David
Published 2014

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

by Ye, Lan, Varamini, Behzad, Baur, Joseph A., Sabatini, David, Lamming, Dudley W.
Published 2018

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

by Robida-Stubbs, Stacey, Glover-Cutter, Kira, Lamming, Dudley W, Mizunuma, Masaki, Narasimhan, Sri Devi, Neumann-Haefelin, Elke, Sabatini, David M, Blackwell, T. Keith, Lamming, Dudley W., Sabatini, David
Published 2014

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

by Lamming, Dudley W., Ye, Lan, Astle, Clinton M., Baur, Joseph A., Harrison, David E., Sabatini, David
Published 2015

The TSC-mTOR pathway regulates macrophage polarization

by Byles, Vanessa, Covarrubias, Anthony J., Ben-Sahra, Issam, Lamming, Dudley W., Manning, Brendan D., Horng, Tiffany, Sabatini, David
Published 2015

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

by Lamming, Dudley W., Mihaylova, Maria M., Katajisto, Pekka, Baar, Emma L., Yilmaz, Omer, Hutchins, Amanda W., Gultekin, Yetis, Gaither, Rachel P., Sabatini, David M.
Published 2014

Rapamycin Doses Sufficient to Extend Lifespan Do Not Compromise Muscle Mitochondrial Content or Endurance

by Ye, Lan, Widlund, Anne L., Sims, Carrie A., Lamming, Dudley W., Guan, Yuxia, Davis, James G., Harrison, David E., Vang, Ole, Baur, Joseph A., Sabatini, David
Published 2015

SYK kinase mediates brown fat differentiation and activation

by Knoll, Marko, Winther, Sally, Natarajan, Anirudh, Yang, Huan, Jiang, Mengxi, Thiru, Prathapan, Shahsafaei, Aliakbar, Chavarria, Tony E., Lamming, Dudley W., Sun, Lei, Hansen, Jacob B., Lodish, Harvey F
Published 2018

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

by Mercken, Evi M., Crosby, Seth D., Lamming, Dudley W., JeBailey, Lellean, Krzysik-Walker, Susan, Villareal, Dennis T., Capri, Miriam, Franceschi, Claudio, Zhang, Yongqing, Becker, Kevin, de Cabo, Rafael, Fontana, Luigi, Sabatini, David
Published 2015

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

by Lamming, Dudley W., Ye, Lan, Katajisto, Pekka, Goncalves, Marcus D., Saitoh, Maki, Stevens, Deanna M., Davis, James G., Salmon, Adam B., Richardson, Arlan, Ahima, Rexford S., Guertin, David A., Baur, Joseph A., Sabatini, David
Published 2014

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

by Lamming, Dudley W., Soliman, Mohamed A., Abdel Rahman, Anas M., Birsoy, Kivanc, Pawling, Judy, Frigolet, Maria E., Lu, Huogen, Fantus, I. George, Pasculescu, Adrian, Zheng, Yong, Dennis, James W., Pawson, Tony, Sabatini, David
Published 2015

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

by Katajisto, Pekka, Lamming, Dudley W., Gultekin, Yetis, Bauer-Rowe, Khristian E., Sengupta, Shomit, Birsoy, Kivanc, Dursun, Abdulmetin, Yilmaz, V. Onur, Selig, Martin, Nielson, G. Petur, Mino-Kenudson, Mari, Zuckerberg, Lawrence, Bahn, Atul K., Deshpande, Vikram, Yilmaz, Omer, Sabatini, David
Published 2012

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

by Saadatpour, Assieh, Hong, Sue-Jean, Pinello, Luca, Katz, Yarden, Lamming, Dudley W., Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Beyaz, Semir, Mana, Miyeko, Roper, Jatin, Kedrin, Dmitriy, Bauer-Rowe, Khristian E., Xifaras, Michael, Akkad, Adam, Arias, Erika, Shinagare, Shweta, Abu-Remaileh, Monther, Dogum, Rizkullah, Sabatini, David, Yilmaz, Omer, Mihaylova, Maria M.
Published 2017

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

by Strong, Randy, Miller, Richard A., Antebi, Adam, Astle, Clinton M., Bogue, Molly, Denzel, Martin S., Fernandez, Elizabeth, Flurkey, Kevin, Hamilton, Karyn L., Lamming, Dudley W., Javors, Martin A., de Magalhães, João Pedro, Martinez, Paul Anthony, McCord, Joe M., Miller, Benjamin F., Müller, Michael, Nelson, James F., Ndukum, Juliet, Rainger, G. Ed, Richardson, Arlan, Salmon, Adam B., Simpkins, James W., Steegenga, Wilma T., Nadon, Nancy L., Harrison, David E., Sabatini, David
Published 2017